Although it is increasingly evident that cancer is influenced by signals emanating from tumor
stroma, little is known regarding how changes in stromal gene expression affect epithelial …

Histone acetylation plays an important role in regulating chromatin structure and thus gene
expression. Here we describe the functional characterization of HDAC4, a human histone …

Breast cancer, rather than constituting a monolithic entity, comprises heterogeneous tumors
with different clinical characteristics, disease courses, and responses to specific treatments. …

Histone (de)acetylation is important for the regulation of fundamental biological processes
such as gene expression and DNA recombination. Distinct classes of histone deacetylases (…

Cancer cell metabolism is often characterized by a shift from an oxidative to a glycolytic
bioenergetics pathway, a phenomenon known as the Warburg effect. miR-378 ∗ is embedded …

Understanding the tumor immune microenvironment (TIME) promises to be key for optimal
cancer therapy, especially in triple-negative breast cancer (TNBC). Integrating spatial …

LCoR (ligand-dependent corepressor) is a transcriptional corepressor widely expressed in
fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single …

Melanoma is an immunogenic cancer with a high response rate to immune checkpoint
inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a result, …

Purpose: Although the murine orthologue of glycoprotein nonmetastatic B (GPNMB),
Osteoactivin, promotes breast cancer metastasis in an in vivo mouse model, its importance in …

Histone acetylation, a reversible modification of the core histones, is widely accepted to be
involved in remodeling chromatin organization for genetic reprogramming. Histone …