Objective. —To review the scientific evidence concerning the safety and efficacy of various
antihypertensive therapies used as first-line agents and evaluated in terms of major disease …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Prior research has found that affect and affective imagery strongly influence public support
for global warming. This article extends this literature by exploring the separate influence of …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Objective. —To assess the association between first myocardial infarction and the use of
antihypertensive agents. Design and Setting. —We conducted a population-based case-control …

Current routine genotyping methods typically do not provide haplotype information, which is
essential for many analyses of fine-scale molecular-genetics data. Haplotypes can be …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Previous genome-wide association studies (GWASs) of stroke — the second leading cause
of death worldwide — were conducted predominantly in populations of European ancestry 1 …

Continued reliance on the androgen receptor (AR) is now understood as a core mechanism
in castration-resistant prostate cancer (CRPC), the most advanced form of this disease. …