Eph receptor tyrosine kinases and their Ephrin ligands represent an important signaling
system with widespread roles in cell physiology and disease. Receptors and ligands in this …

The chemokine stromal-derived factor-1 (SDF-1) and its unique receptor, CXCR4, are required
for normal cardiovascular development, but a critical role for SDF-1 in postnatal vascular …

The chemokine receptor CXCR4 is an important factor in the migration, invasiveness, metastasis
and proliferation of breast cancer cells. We have retrospectively analyzed the levels of …

The chemokine stromal-derived factor-1 (SDF-1), which is constitutively expressed in most
tissues as SDF-1α and SDF-1β resulting from alternative gene splicing, regulates …

CXCR4 is a chemokine receptor implicated in the homing of cancer cells to target metastatic
organs, which overexpress its ligand, stromal cell‐derived factor (SDF)‐1. To determine the …

Endothelial-to-mesenchymal transition (EndMT) is now widely considered a pivotal
contributor to cancer progression. In this study, we show that the Kaposi's sarcoma (KS)–associated …

EphrinB transmembrane ligands and their cognate EphB receptor tyrosine kinases regulate
vascular development through bidirectional cell-to-cell signaling, but little is known about the …

Formation of new vessels during development and in the mature mammal generally proceeds
through angiogenesis. Although a variety of molecules and signaling pathways are known …

The complex molecular mechanisms that drive endothelial cell movement and the formation
of new vessels are poorly understood and require further investigation. Eph receptor …

… NO, resulting from the enzymatic activity of NOS, is a labile molecule that, in aqueous
solution, reacts rapidly with O 2 and accumulates in the culture medium as nitrite and nitrate(38). …