Acute myeloid leukemia (AML) is a heterogeneous disease that resides within a complex
microenvironment, complicating efforts to understand how different cell types contribute to …

The blood system is sustained by a pool of haematopoietic stem cells (HSCs) that are long-lived
due to their capacity for self-renewal. A consequence of longevity is exposure to stress …

Xenograft studies indicate that some solid tumors and leukemias are organized as cellular
hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model, its …

Intratumoral heterogeneity arises through the evolution of genetically diverse subclones
during tumor progression. However, it remains unknown whether cells within single genetic …

The combination of single-cell transcriptomics with mitochondrial DNA variant detection can
be used to establish lineage relationships in primary human cells, but current methods are …

Genome-wide profiling of histone modifications can provide systematic insight into the
regulatory elements and programs engaged in a given cell type. However, conventional …

Lifelong maintenance of the blood system requires equilibrium between clearance of
damaged hematopoietic stem cells (HSCs) and long-term survival of the HSC pool. Severe …

Tumor recurrence following treatment remains a major clinical challenge. Evidence from
xenograft models and human trials indicates selective enrichment of cancer-initiating cells (CICs…

The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising
therapies entering clinical translation, yet patient responses remain heterogeneous, and …

Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily
in the midline of the central nervous system of young children, suggesting a cooperation …