… study identified two novel compounds 3 R,4 R)− 1-(7a-Methyl-5-oxo-2,3,6,7-tetrahydropyrrolo[2,1-b][1],
[3]thiazole-3-carbonyl)− 4-phenylpyrrolidine-3-carboxylic acid and (3 R,4 R)− 1-(3…

Cytoskeleton-associated protein 4 (CKAP4) is a non-glycosylated type II transmembrane
protein that serves as a cell surface-activated receptor. It is expressed primarily in the plasma …

Long non-coding-RNAs (lncRNAs) are an expanding set of cis-/trans-regulatory RNA genes
that outnumber the protein-coding genes. Although being increasingly discovered, the …

Homeodomain-interacting protein kinase 1 (HIPK1) is majorly found in the nucleoplasm.
HIPK1 is associated with cell proliferation, tumor necrosis factor-mediated cellular apoptosis, …

Thousand and one amino acid kinase 1 (TAOK1) is a sterile 20 family Serine/Threonine
kinase linked to microtubule dynamics, checkpoint signaling, DNA damage response, and …

… feature types: Hydrogen bond acceptors (A), hydrogen bond donors (D), hydrophobic groups
(H), negatively ionizable groups (N), positively ionizable groups (P), and aromatic rings (R). …

In this study, we explored the potential of novel inhibitors for FYN kinase, a critical target in
cancer and neurodegenerative disorders, by integrating advanced cheminformatics, machine …

Glial cell line-derived neurotrophic factor (GDNF) signals through a multi-component receptor
system predominantly consisting of glycosyl-phosphatidylinositol-anchored GDNF family …

CHK-1 kinase belongs to the serine/threonine family of kinases, which play a vital role in cell
cycle arrest and proved to be a promising therapeutic target to control cancer development …

Trophoblast cell surface antigen 2 (TROP2) is a calcium-transducing transmembrane protein
mainly involved in embryo development. The aberrant expression of TROP2 is observed in …