Cancer stem cells: models and concepts
P Dalerba, RW Cho, MF Clarke - Annu. Rev. Med., 2007 - annualreviews.org
Although monoclonal in origin, most tumors appear to contain a heterogeneous population
of cancer cells. This observation is traditionally explained by postulating variations in tumor …
of cancer cells. This observation is traditionally explained by postulating variations in tumor …
Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia
Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available
medications. Thus, understanding the neural basis of these deficits is crucial for the …
medications. Thus, understanding the neural basis of these deficits is crucial for the …
Recent advances in cancer stem cells
RW Cho, MF Clarke - Current opinion in genetics & development, 2008 - Elsevier
The theory of cancer stem cells states that a subset of cancer cells within a tumor has the
ability to self-renew and differentiate. Only those cells within a tumor that have these two …
ability to self-renew and differentiate. Only those cells within a tumor that have these two …
[PDF][PDF] Genomic classification of cutaneous melanoma
We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
[PDF][PDF] A genome-wide transcriptional analysis of the mitotic cell cycle
Progression through the eukaryotic cell cycle is known to be both regulated and accompanied
by periodic fluctuation in the expression levels of numerous genes. We report here the …
by periodic fluctuation in the expression levels of numerous genes. We report here the …
Association of reactive oxygen species levels and radioresistance in cancer stem cells
The metabolism of oxygen, although central to life, produces reactive oxygen species (ROS)
that have been implicated in processes as diverse as cancer, cardiovascular disease and …
that have been implicated in processes as diverse as cancer, cardiovascular disease and …
Phenotypic characterization of human colorectal cancer stem cells
Recent observations indicate that, in several types of human cancer, only a phenotypic
subset of cancer cells within each tumor is capable of initiating tumor growth. This functional …
subset of cancer cells within each tumor is capable of initiating tumor growth. This functional …
Anterior cingulate conflict monitoring and adjustments in control
Conflict monitoring by the anterior cingulate cortex (ACC) has been posited to signal a need
for greater cognitive control, producing neural and behavioral adjustments. However, the …
for greater cognitive control, producing neural and behavioral adjustments. However, the …
Systematic determination of genetic network architecture
Technologies to measure whole-genome mRNA abundances 1, 2, 3 and methods to
organize and display such data 4, 5, 6, 7, 8, 9, 10 are emerging as valuable tools for systems-level …
organize and display such data 4, 5, 6, 7, 8, 9, 10 are emerging as valuable tools for systems-level …
A network-based analysis of systemic inflammation in humans
Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically
similar tumours, monitor disease progress, and individualize treatment regimens 1 , 2 , …
similar tumours, monitor disease progress, and individualize treatment regimens 1 , 2 , …