Glial cell line-derived neurotrophic factor (GDNF): a drug candidate for the treatment of Parkinson's disease

R Grondin, DM Gash - Journal of neurology, 1998 - Springer
Considerable effort has been devoted to the search for molecules that might exert trophic
influences on midbrain dopamine neurons, and potentially be of therapeutic value in the …

Wide-area measurement based stabilizing control of large power systems-a decentralized/hierarchical approach

I Kamwa, R Grondin, Y Hébert - IEEE Transactions on power …, 2001 - ieeexplore.ieee.org
The aim of this paper is to assess the capability of the emerging synchronized phasor
measurement technology in improving the overall stability of the Hydro-Quebec transmission …

Endoscopic versus microsurgical resection of third ventricle colloid cysts

RT Grondin, W Hader, ME MacRae… - Canadian journal of …, 2007 - cambridge.org
Objective:Endoscopic resection of colloid cysts has been performed as an alternative to
microsurgical resection and stereotactic aspiration since 1982. To date, there are limited …

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

…, DM Gash, GA Gerhardt, R Grondin… - Proceedings of the …, 2004 - National Acad Sciences
We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor
dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were …

IEEE PSS2B versus PSS4B: the limits of performance of modern power system stabilizers

I Kamwa, R Grondin, G Trudel - IEEE transactions on power …, 2005 - ieeexplore.ieee.org
IEEE Std 421.5 as revised by the IEEE excitation system subcommittee will introduce a new
type of power system stabilizer model, the multiband power system stabilizers (PSSs). …

Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys

R Grondin, Z Zhang, A Yi, WA Cass, N Maswood… - Brain, 2002 - academic.oup.com
The powerful trophic effects that glial cell line‐derived neurotrophic factor (GDNF) exerts on
midbrain dopamine neurones suggest its use in treating Parkinson’s disease. However, …

Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys

R Grondin, PJ Bedard, AH Tahar, L Gregoire, A Mori… - Neurology, 1999 - AAN Enterprises
Background: Chronic treatment with l-3,4-dihydroxyphenylalanine (l-dopa) is often associated
with motor side effects in PD patients. The search for new therapeutic approaches has led …

[PDF][PDF] Molecular basis of levodopa-induced dyskinesias

F Calon, R Grondin, M Morissette, M Goulet… - Annals of …, 2000 - researchgate.net
A series of experiments were performed in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
(MPTP) model of parkinsonism for the purpose of understanding the mechanism of …

Point source concentration of GDNF may explain failure of phase II clinical trial

…, Y Ai, B Fischer, AM Zhang, RC Grondin… - Experimental …, 2006 - Elsevier
Significant differences have been reported in results from three clinical trials evaluating
intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) for the treatment of …

Fast adaptive schemes for tracking voltage phasor and local frequency in power transmission and distribution systems

I Kamwa, R Grondin - IEEE Transactions on Power Delivery, 1992 - ieeexplore.ieee.org
Two learning schemes are proposed for fast estimation of voltage phasor and local
frequency deviation. The problem was addressed from a system identification perspective, in …