The use of crop wild relatives (CWR) genes to improve crop performance is well established
with important examples dating back more than 60 years. In this paper, we review available …

Heart disease remains the leading cause of death and disability in the Western world.
Current therapies aim at treating the symptoms rather than the subcellular mechanisms, …

Few studies have addressed the relationship between genetic diversity and provision of
ecosystem services in agroecosystems. In this review, we argue that the contribution of …

Background Heart failure can result from a variety of causes, including ischemic, hypertensive,
toxic, and inflammatory heart disease. However, the cellular mechanisms responsible for …

Background To test whether deficiency in endothelial nitric oxide synthase (eNOS) affects
atherosclerosis development, we compared lesion formation in apolipoprotein E (apoE)/eNOS-…

Characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure,
dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy in patients. DCM is …

Background The serine-threonine kinase Akt is activated by several ligand-receptor systems
previously shown to be cardioprotective. Akt activation reduces cardiomyocyte apoptosis in …

… Dr Hajjar has ownership interest (includes stock and stock options and rights in patents) in
… K, Dittrich H, Zsebo K, Hajjar R ; Calcium Upregulation by Percutaneous Administration of …

… Hajjar, Keating, McGowan, and Pu laboratories for discussions and sharing reagents; SP
Sardi (Children's Hospital Boston, Boston, Massachusetts, USA) for lentivirus constructs; and R…

In human and experimental models of heart failure, sarcoplasmic reticulum Ca 2+ ATPase (SERCA2a)
activity is decreased, resulting in abnormal calcium handling. The disturbances in …