Objective: To revise the “Clinical Practice Guidelines for the Sustained Use of Sedatives and
Analgesics in the Critically Ill Adult” published in Critical Care Medicine in 2002. Methods: …

The GRADE (Grades of Recommendation, Assessment, Development, and Evaluation)
approach provides guidance to grading the quality of underlying evidence and the strength of …

CLINICAL SCENARIO A 55-year-old man had his serum cholesterol level measured at a
shopping mall 2 months ago. His cholesterol level was elevated and he comes to you, his …

Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A consensus …

Objective: To provide an update to the original Surviving Sepsis Campaign clinical management
guidelines,“Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis …

This article is the first of a series providing guidance for use of the Grading of Recommendations
Assessment, Development, and Evaluation (GRADE) system of rating quality of …

In recent years quality of life instruments have been featured as primary outcomes in many
randomized trials. One of the challenges facing the investigator using such measures is …

CLINICAL SCENARIO You are back where we put you in the previous article 1 on diagnostic
tests in this series on how to use the medical literature: in the library studying an article that …

BACKGROUND: In the past only physiological and clinical outcomes have been used to
assess the effect of asthma interventions and the effect of the intervention on the lives of the …

GRADE suggests that examination of 95% confidence intervals (CIs) provides the optimal
primary approach to decisions regarding imprecision. For practice guidelines, rating down the …