This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant
history of Dr. James Parkinson's himself and what he described accurately and what he …

This article describes research criteria and probability methodology for the diagnosis of
prodromal PD. Prodromal disease refers to the stage wherein early symptoms or signs of PD …

This document presents the Movement Disorder Society Clinical Diagnostic Criteria for
Parkinson's disease (PD). The Movement Disorder Society PD Criteria are intended for use in …

Background Aggregated α-synuclein plays an important role in the pathogenesis of Parkinson’s
disease. The monoclonal antibody prasinezumab, directed at aggregated α-synuclein, is …

Objective: Idiopathic REM sleep behavior disorder (RBD) is a potential preclinical marker for
the development of neurodegenerative diseases, particularly Parkinson disease (PD) and …

Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson’s
disease, dementia with Lewy bodies, and multiple system atrophy. This provides an …

The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about
the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in …

Background Aggregated α-synuclein plays an important role in Parkinson’s disease
pathogenesis. Cinpanemab, a human-derived monoclonal antibody that binds to α-synuclein, is …

… Conflict of Interest Disclosures: Dr Postuma received personal compensation for travel and
speaker fees from Novartis Canada, Biotie, and Teva Neurosciences and is funded by grants …

With advances in knowledge disease, boundaries may change. Occasionally, these changes
are of such a magnitude that they require redefinition of the disease. In recognition of the …