A main pathway used by cytotoxic T lymphocytes (CTLs) and natural killer cells to eliminate
pathogenic cells is via exocytosis of granule components in the direction of the target cell, …

Background Registry data on patients with type 1 diabetes mellitus who undergo pancreatic
islet transplantation indicate that only 8 percent are free of the need for insulin therapy at …

Many sites have been tested in an effort to identify the most ideal site to support islet
function and viability. The aim of this study was to evaluate an omental pouch site for islet …

Islet transplantation offers the prospect of good glycemic control without major surgical risks.
After our initial report of successful islet transplantation, we now provide further data on 12 …

Clinical islet transplantation is gaining acceptance as a potential therapy, particularly for
subjects who have labile diabetes or problems with hypoglycemic awareness. The risks of the …

Recent progress in islet isolation from the pancreas of large mammals including man,
accentuated the need for the development of precise and reproducible techniques to assess islet …

We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in
pancreatectomized rhesus macaques. Although porcine islets transplanted into …

A miniature, needle-type glucose sensor based on a new trilayer membrane configuration
has been prepared and evaluated both in vitro and in vivo. The perfluorinated ionomer, Nafion…

… Rabinovitch, and RV Rajotte. 1991. Normoglycemia after transplantation of freshly
isolated and cryopreserved pancreatic islets in type 1 (insulin-dependent) diabetes mellitus. …

Genetic engineering of non-β cells to release insulin upon feeding could be a therapeutic
modality for patients with diabetes. A tumor-derived K-cell line was induced to produce human …