Tumor recurrence following treatment remains a major clinical challenge. Evidence from
xenograft models and human trials indicates selective enrichment of cancer-initiating cells (CICs…

Nonsense mutations, resulting in a premature stop codon in the open reading frame of
mRNAs are responsible for thousands of inherited diseases. Readthrough of premature stop …

BMI-1, also known as a stem cell factor, is frequently upregulated in several malignancies.
Elevated expression of BMI-1 correlates with poor prognosis and is therefore considered a …

Two model studies in support of a total synthesis of the complex polycyclic alkaloid daphnilactone
B have been completed. The objectives of the models studies were to demonstrate the …

An asymmetric synthesis of the ABCD ring system of daphnilactone B is described. The
synthesis features a tandem, double intramolecular, [4+2]/[3+2] cycloaddition of a highly …

Nonsense mutations resulting in a premature stop codon in an open reading frame occur in
critical tumor suppressor genes in a large number of the most common forms of cancers and …

Medulloblastoma (MB) is the most frequent malignant pediatric brain tumor, representing 20%
of newly diagnosed childhood central nervous system malignancies. Although advances …

Using small molecules to induce readthrough of premature termination codons is a promising
therapeutic approach to treating genetic diseases and cancers caused by nonsense …

Chemoselective S NAr reactions of 4,6-dichloro-2-(methylsulfonyl)pyrimidine and several
related electrophiles with amines and their derivatives are described. In the presence of weak …

An asymmetric synthesis of the ABCD ring system of daphnilactone B is described. The
synthesis features a tandem, double intramolecular,[4+ 2]/[3+ 2] cycloaddition of a highly …