A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes

SA Rosenberg, P Spiess, R Lafreniere - Science, 1986 - science.org
The adoptive transfer of tumor-infiltrating lymphocytes (TIL) expanded in interleukin-2 (IL-2)
to mice bearing micrometastases from various types of tumors showed that TIL are 50 to 100 …

Successful immunotherapy of murine experimental hepatic metastases with lymphokine-activated killer cells and recombinant interleukin 2

R Lafreniere, SA Rosenberg - Cancer Research, 1985 - AACR
Lymphokine-activated killer (LAK) cells are generated in vitro by the incubation of normal
murine splenocytes in interleukin 2. We have shown previously that the systemic injection of …

A novel approach to the generation and identification of experimental hepatic metastases in a murine model

R Lafreniere, SA Rosenberg - Journal of the National Cancer …, 1986 - academic.oup.com
A reproducible model for the selective generation of liver metastases has been developed.
The spleen is exteriorized by means of a small subcostal incision and is directly injected with …

Adoptive immunotherapy of murine hepatic metastases with lymphokine activated killer (LAK) cells and recombinant interleukin 2 (RIL 2) can mediate the regression …

R Lafreniere, SA Rosenberg - Journal of immunology (Baltimore …, 1985 - journals.aai.org
The incubation of normal murine splenocytes in recombinant interleukin 2 (RIL 2) gives rise
to lymphokine-activated killer (LAK) cells that are specifically cytotoxic to fresh noncultured, …

Impact of surgeon training on outcomes after resective hepatic surgery

A McKay, I You, D Bigam, R Lafreniere… - Annals of Surgical …, 2008 - Springer
Background Higher hospital and surgeon volumes have been associated with improved
outcomes after hepatic resection. Subspecialty training has not previously been associated with …

Bloody nipple discharge during pregnancy: a rationale for conservative treatment

R Lafreniere - Journal of surgical oncology, 1990 - Wiley Online Library
Five cases of bloody nipple discharge during pregnancy without associated breast masses
were seen over the past 3 years by the author. Because of the reported association of breast …

Gestational macromastia

R Lafreniere, W Temple, A Ketcham - The American journal of surgery, 1984 - Elsevier
… Requests for reprints should be addressed to Rene Lafreniere. MD, Department Of Swgwy
(R-310), University of Miami School of Medicine, PO Box 016310, Miami. Florida 33101. …

Primary squamous carcinoma of the rectum: report of a case and review of the literature

R Lafreniere, AS Ketcham - Diseases of the colon & rectum, 1985 - journals.lww.com
: Squamous cell carcinoma of the colorectum is a rare pathologic curiosity. Since the first
report by Schmidtman in 1919, only 69 cases have been reported in the English medical …

Infection control in the operating room: current practices or sacred cows?

R Lafrenière, JMA Bohnen, J Pasieka… - Journal of the American …, 2001 - journals.lww.com
René Lafreniere, MD, FRCSC, FACS: The issue of infection control in the operating room is
an everyday concern for all members of the operating room team. We as surgeons, …

Introduction of new technologies and decision making processes: a framework to adapt a local health technology decision support program for other local settings

…, M Poulin, N Gall, J Seidel, R Lafrenière - Medical devices …, 2013 - Taylor & Francis
Purpose Introducing new health technologies, including medical devices, into a local setting
in a safe, effective, and transparent manner is a complex process, involving many …