This article summarizes the views expressed at the third session of the workshop "Tissue
Engineering—The Next Generation," which was devoted to the engineering of complex tissue …

Connective tissues tend to heal naturally and successfully only if the injury is minor. If the
damage is more severe, then a good functional result can be achieved only if Nature is …

Background External-beam radiotherapy (delivered either preoperatively or postoperatively)
is frequently used in local management of sarcomas in the soft tissue of limbs, but the two …

BACKGROUND AND PURPOSE: This study compared late radiation morbidity in patients
with extremity soft tissue sarcoma randomized to treatment by pre- (50Gy) or postoperative (…

Background: Malignant gastrointestinal stromal tumors (M-GIST) are rare mesenchymal
tumors originating in the wall of the gastrointestinal (GI) tract. Previous studies have included …

Study Design. This study examines changes in the production of extracellular matrix molecules
as well as the induction of tissue degradation in in vitro formed nucleus pulposus (NP) …

Low back pain is a major physical and socioeconomic problem. Degeneration of the intervertebral
disc and especially that of nucleus pulposus (NP) has been linked to low back pain. In …

Sixty-five patients who had been referred to our unit for additional management after an
unplanned excision of a soft-tissue sarcoma of an extremity at another institution were studied …

Background A reliable and reproducible method is needed to assess cartilage repair. Purpose
This study was undertaken to test the reproducibility of 2 established histological scoring …

Although many cancers are maintained by tumor-initiating cells, this has not been shown for
mesenchymal tumors, in part due to the lack of unique surface markers that identify …