Objective To determine the safety and efficacy of etanercept in a multicenter, randomized,
placebo‐controlled, double‐blind trial of adults with moderate to severe active ankylosing …

The appropriate federal structure of government is now a policy issue of major debate. This
paper identifies three approaches and compares their strengths and weaknesses. Economic …

Recent changes in the institutions of government economic policymak-ing in western and
eastern Europe, efforts to write new constitutions for Russia and South Africa, and the less …

To update and integrate the recommendations for ankylosing spondylitis and the recommendations
for the use of tumour necrosis factor inhibitors (TNFi) in axial spondyloarthritis (axSpA…

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …

Therapeutic targets have been defined for axial and peripheral spondyloarthritis (SpA) in
2012, but the evidence for these recommendations was only of indirect nature. These …

Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting
primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been …

Autoimmune disease is the consequence of an immune response against self-antigens that
results in the damage and eventual dysfunction of target organs. Although the triggering …

Objective Recent studies have shown that a nonsynonymous single‐nucleotide polymorphism
(SNP) (Arg381Gln; rs11209026) in the interleukin‐23 receptor (IL‐23R) gene on …

Objective: To develop evidence based recommendations for the management of ankylosing
spondylitis (AS) as a combined effort of the ‘ASsessment in AS’ international working group …