The chronic low-level inflammation associated with obesity is known to deleteriously affect
muscle composition. However, the manner in which obesity leads to muscle loss has not …

Obesity, and corresponding chronic‐low grade inflammation, is associated with the onset
and progression of knee OA. The origin of this inflammation is poorly understood. Here, the …

Osteoarthritis is the most common joint disorder with aging, but its cause is unknown. Mice
lose joint afferents with aging, and this loss precedes development of osteoarthritis. We …

The influence of obesity on muscle integrity is not well understood. The purpose of this study
was to quantify structural and molecular changes in the rat vastus lateralis (VL) muscle as a …

Previous work has shown that innervation participates in normal ligament healing. The present
study was performed to determine if exogenous nerve growth factor (NGF) would improve …

The effects of obesity on different musculoskeletal tissues are not well understood. The glycolytic
quadriceps muscles are compromised with obesity, but due to its high oxidative capacity…

Background Walking and running provide cyclical loading to the knee which is thought
essential for joint health within a physiological window. However, exercising outside the …

OBJECTIVE: Murine brachymorphism (bm) results from an autosomal recessive mutation of
the Papss2 gene that encodes 3′-phosphoadenosine 5′-phosphosulfate synthetase 2, …

Background Osteoarthritis is one of the leading causes of pain and disability worldwide, and
a large percentage of patients with osteoarthritis are individuals who are also obese. In …

Degeneration of articular cartilage is often triggered by a small tissue crack. As cartilage
structure and composition change with age, the mechanics of cracked cartilage may depend on …