… At 52 C, they usually respond within 10–30 s. At this temperature, we use a cut-off time of 30
s … ’s response. It is thus possible to repeat the test 3–4 times and to average the test results. …

Background Biliary tract malignancies, in particular cholangiocarcinomas (CCA), are rare
tumors that carry a poor prognosis. BRCA2 mutation carriers have an increased risk of …

It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have
been positively selected during human evolution due to effects on aspects of speech and …

… S. Moura reports receiving speakers bureau honoraria from Celgene Corporation. JMS
Bartlett holds ownership interest (including patents) in 61 Due North, BioNTech, Biotheranostics, …

Purpose The main purpose of this study was to determine the prevalence of pathogenic BRCA1
and BRCA2 mutations in a consecutively ascertained clinic-based cohort of patients with …

Background: The BRCA1/2 proteins are involved in regulation of cellular proliferation by DNA
damage repair via homologous recombination. Therefore, BRCA1/2 mutation carriers with …

… Several other parameters were shown to be higher in J than in N mice in at least two
centers, but in each case the other center(s) reported no significant differences in the same …

… age, specific PMS2 mutation, site of CRC, age(s) at diagnosis of CRC, other non-CRC cancer
… genetic and epidemiologic studies that might one day make known today’s unknowns. …

… Longevity effects of rapamycin may, however, be due to rapamycin’s effects on specific
life-… Therefore, our data largely dissociate rapamycin’s longevity effects from effects on aging …

… Mutation prevalence estimates in these subpopulations were computed from the Horvitz–Thompson
estimator incorporating sample weights and compared using Rao and Scott’s …