A consensus meeting was convened by the Initiative on Methods, Measurement, and Pain
Assessment in Clinical Trials (IMMPACT) to provide recommendations for interpreting clinical …

Abstract Interpretation of clinical trials comparing different drug regimens for Parkinson's
disease (PD) is complicated by the different dose intensities used: higher doses of levodopa and…

Background There is a scarcity of published data on the global prevalence of obstructive
sleep apnoea, a disorder associated with major neurocognitive and cardiovascular sequelae. …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements
in the human genome sequence. The pilot phase of the Project is focused on a specified …

IN Western Europe and the United States approximately 1 in 12 women develop breast cancer.
A small proportion of breast cancer cases, in particular those arising at a young age, are …

Background Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects.
The long-term efficacy and safety of edoxaban as compared with warfarin in patients with …

Preclinical mouse models suggest that the gut microbiome modulates tumor response to
checkpoint blockade immunotherapy; however, this has not been well-characterized in human …

Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated
and has reduced protein-coding potential. The genomic origins and the associations of …

TUMOUR necrosis factor-α (TNF-α) is a potent pro-inflammatory and immunomodulatory
cytokine implicated in inflammatory conditions such as rheumatoid arthritis, Crohn's disease, …