Despite stress-associated disorders having a higher incidence rate in females, preclinical
research mainly focuses on males. Chronic stress paradigms, such as chronic social defeat …

Rationale Some mood disorders, such as major depressive disorder, are more prevalent in
women than in men. However, historically preclinical studies in rodents have a lower …

Background Rindopepimut (also known as CDX-110), a vaccine targeting the EGFR deletion
mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole limpet …

Importance Proponents of novel transanal total mesorectal excision (TME) suggest the
procedure overcomes the technical and oncologic challenges of conventional approaches for …

… In 2016, the first Canadian taTME congress was held in the city of Toronto, organized by
two of the authors [EV, SA] under the auspice of the University of Toronto, which was followed …

Object The object of this study was to investigate the use of a minimally invasive technique
for treating metastatic tumors of the vertebral body, aimed at relieving pain, preventing further …

… Images for SA-β-gal quantifications were acquired using a ZEISS Axio Vert.A1 inverted
microscope at 10x magnification. For each biological replicate, an area of the well was randomly …

Thirty percent of colon cancer diagnoses occur following emergency presentations, often
with bowel obstruction or perforation requiring urgent surgery. We sought to compare cancer …

ONC201 is a first-in-class imipridone molecule currently in clinical trials for the treatment of
multiple cancers. Despite enormous clinical potential, the mechanism of action is …

Introduction Resection for isolated distant recurrence of colon cancer is well accepted. Resection
for locoregionally recurrent colon cancer (LRCC) is not well studied. We evaluated the …