Burkitt's lymphoma is a highly aggressive B-cell non-Hodgkin lymphoma and is the fastest
growing human tumour. The disease is associated with Epstein-Barr virus and was one of the …

Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological
variables pertaining to age, presence of metastases, extent of resection, histological …

A large number of studies have been undertaken in recent years aimed at furthering our
understanding of the complex mechanisms underlying the common and debilitating condition of …

The aqueous electrochemistry of a number of quinones and two hydroxyquinones was studied
using cyclic voltammetry. The quinones were chosen to represent a variety of structural …

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …

Relationships between physicochemical drug properties and toxicity were inferred from a
data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer …

Medulloblastoma is heterogeneous, being characterized by molecular subgroups that
demonstrate distinct gene expression profiles. Activation of the WNT or SHH signaling pathway …

Although crizotinib demonstrates robust efficacy in anaplastic lymphoma kinase (ALK)-positive
non-small-cell lung carcinoma patients, progression during treatment eventually develops…

Purpose Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer
conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup …

Background International consensus recognises four medulloblastoma molecular subgroups:
WNT (MB WNT ), SHH (MB SHH ), group 3 (MB Grp3 ), and group 4 (MB Grp4 ), each …