Human coronavirus, hCoV-19, is highly pathogenic with severe pneumonia associated with
rapid virus replication. Arising in Wuhan China December 2019, the current COVID-19 …

The immune system of mammals developed an exquisite ability to discriminate between"
self" and" non-self" with non-self normally being potential pathogens of foreign origin. This …

… Metcalfe SM. Axotrophin and leukemia inhibitory factor (LIF) in transplantation tolerance. …
Chen Z, Cobbold SP, Waldmann H, Metcalfe S. Amplification of natural regulatory immune …

At the heart of lineage commitment within the adaptive immune response is the intrinsic genetic
plasticity of the naive peripheral T lymphocyte (T cell). Primary activation by presentation …

Two major hurdles need to be surmounted for cell therapy for diabetes: (i) allo-immune rejection
of grafted pancreatic islets, or stem/precursor cell-derived insulin-secreting cells; and (ii) …

The spectra of non-covalent spin labels have been examined in the presence of erythrocyte
membranes and their separated lipid and protein components. Evidence has been obtained …

Nanotechnology permits the design of therapeutic devices with defined structure and
molecular composition. Modular designs employing surface-bound ligands provide specific …

Background. The specific regulation of allo-tolerance in vivo occurs within a complex
microenvironment and involves co-operation between a small proportion of different cell types …

Leukaemia inhibitory factor (LIF) plays a critical role in" stemness" versus" differentiation", a
property that underpins the core value of LIF as a therapeutic for both the treatment of …

… This research was supported by grants to SM including GMSI 2014 Award from Merck Serono
and grants from Innovate UK including Smart Award 2015 and Biomedical Catalyst Award …