Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Importance Little is known about the relationship between perioperative high-sensitivity
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …

The Canadian Cardiovascular Society Guidelines Committee and key Canadian opinion
leaders believed there was a need for up to date guidelines that used the Grading of …

Objectives A P-value <0.05 is one metric used to evaluate the results of a randomized controlled
trial (RCT). We wondered how often statistically significant results in RCTs may be lost …

Objective To investigate the credibility of authors’ claims of subgroup effects using a representative
sample of recently published randomised controlled trials. Design Systematic review. …

Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …

Background Myocardial injury after non-cardiac surgery (MINS) increases the risk of
cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran …

BACKGROUND: Among adults undergoing contemporary noncardiac surgery, little is
known about the frequency and timing of death and the associations between perioperative …

Background: Preliminary data suggest that preoperative N-terminal pro–B-type natriuretic
peptide (NT-proBNP) may improve risk prediction in patients undergoing noncardiac surgery. …

Background: Among patients having noncardiac surgery, perioperative hemodynamic
abnormalities are associated with vascular complications. Uncertainty remains about what …