In their seminal publication describing the structure of the DNA double helix 1, Watson and
Crick wrote what may be one of the greatest understatements in the scientific literature, …

Human DNA polymerase η (Pol η) modulates susceptibility to skin cancer by promoting
DNA synthesis past sunlight-induced cyclobutane pyrimidine dimers that escape nucleotide …

DNA mismatch repair ensures genomic stability by correcting biosynthetic errors and by
blocking homologous recombination. MutS-like and MutL-like proteins play important roles in …

The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer’s disease
(AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing …

We report a compact two-dimensional accelerometer based upon a simple fiber cantilever
constructed from a short length of multicore optical fiber. Two-axis measurement is …

A DNA lesion created by oxidative stress is 7,8-dihydro-8-oxo-guanine (8-oxoG). Because 8-oxoG
can mispair with adenine during DNA synthesis, it is of interest to understand the …

Xeroderma pigmentosum variant (XPV) patients with mutations in the DNA polymerase η (pol
η) gene are hypersensitive to sunlight and have greatly increased susceptibility to sunlight-…

PURPOSE In primary care, there is increasing recognition of the difficulty of treating patients’
immediate health concerns when their overall well-being is shaped by underlying social …

One of the most common DNA lesions arising in cells is an apurinic/apyrimidinic (AP) site
resulting from base loss. Although a template strand AP site impedes DNA synthesis, …

When cyclobutane pyrimidine dimers stall DNA replication by DNA polymerase (Pol) δ or ϵ,
a switch occurs to allow translesion synthesis by DNA polymerase η, followed by another …