Importance The optimal approach for treatment deescalation in human papillomavirus (HPV)–related
oropharyngeal squamous cell carcinomas (OPSCCs) is unknown. Objective To …

The spatial organization of the tumor microenvironment has a profound impact on biology
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …

Background Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous
cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) …

The differential diagnosis and malignancy risk stratification of thyroid nodules requires
multidisciplinary expertise and knowledge of both local ultrasonography practices and the local …

Importance Oral cavity cancer often requires multidisciplinary management, subjecting
patients to complex therapeutic trajectories. Prolonged treatment intervals in oral cavity cancer …

There are few prognostic biomarkers and targeted therapeutics currently in use for the clinical
management of oral squamous cell carcinoma (OSCC) and patient outcomes remain poor …

Background The objective of this study is to evaluate the cost-effectiveness of a postoperative
clinical care pathway for patients undergoing major head and neck oncologic surgery with …

Simple Summary Chronic opioid use is a serious global health problem and surgery is often
the point of initial exposure for many chronic opioid users. Multimodal analgesia (MMA) is …

Background Our study quantifies the effectiveness of perioperative pain control in a cohort
of patients undergoing major head and neck surgery with free flap reconstruction. Our long-…

Head and neck cancer (HNC) surgical patients experience a high symptom burden. Multiphasic
exercise prehabilitation has the potential to improve patient outcomes, and to implement …