Prostate tumours are highly variable in their response to therapies, but clinically available
prognostic factors can explain only a fraction of this heterogeneity. Here we analysed 200 …

Herein we provide a detailed molecular analysis of the spatial heterogeneity of clinically
localized, multifocal prostate cancer to delineate new oncogenes or tumor suppressors. We …

Background Chromothripsis, a newly discovered type of complex genomic rearrangement,
has been implicated in the evolution of several types of cancers. To date, it has been …

Introduction Endoscopic full-thickness resection (EFTR) with an over-the-scope full-thickness
resection device is a relatively new technique for the resection of colorectal lesions. …

Background The objective of our study was to identify the most common mechanisms of
injury leading to death in our pediatric population. Methods A retrospective cohort of fatally …

Background There is limited literature on the risk of venous thromboembolism (VTE) in
emergency general surgery (EGS) patients. We undertook this study to identify the rate of …

Background We hypothesized that patients living in rural neighborhoods experience delayed
access to surgical services manifesting in increased appendiceal perforation rates in cases …

The creation of an intestinal pouch following total gastrectomy is exceedingly rare in infants.
We present the case of a term infant who underwent a near-total gastrectomy on day 2 of life …

Background Patients with diverticulitis are predisposed to hepatic abscesses via seeding
through the portal circulation. Hepatic abscesses are well-documented sequelae of diverticulitis…

Background: Endoscopic full-thickness resection (EFTR) is a relatively new technique for
the resection of colorectal lesions. Multiple centres have published the results of case series …