User profiles for Sophie Lerouge

Lerouge Sophie

École de technologie supérieure (ÉTS), Montréal, Canada
Verified email at etsmtl.ca
Cited by 4501

Chitosan thermogels for local expansion and delivery of tumor-specific T lymphocytes towards enhanced cancer immunotherapies

A Monette, C Ceccaldi, E Assaad, S Lerouge… - Biomaterials, 2016 - Elsevier
The success of promising anti-cancer adoptive cell therapies relies on the abilities of the
perfused CD8 + T lymphocytes to gain access to and persist within the tumor microenvironment …

3D printing of microstructured and stretchable chitosan hydrogel for guided cell growth

Q Wu, M Maire, S Lerouge, D Therriault… - Advanced …, 2017 - Wiley Online Library
The ability to produce complex micro‐ or nanostructures from naturally derived hydrogels is
significant for biomedical applications. However, precisely controlled architectures of soft …

An injectable chitosan/chondroitin sulfate hydrogel with tunable mechanical properties for cell therapy/tissue engineering

…, A Adoungotchodo, E Hui, F Zehtabi, S Lerouge - International journal of …, 2018 - Elsevier
Chitosan (CH) hydrogels with remarkable mechanical properties and rapid gelation rate were
recently synthesized by combining sodium hydrogen carbonate (SHC) with another weak …

Injectable thermosensitive chitosan hydrogels with controlled gelation kinetics and enhanced mechanical resistance

E Assaad, M Maire, S Lerouge - Carbohydrate polymers, 2015 - Elsevier
The use of injectable hydrogels is presently limited by the difficulty to achieve rapid gelation,
high mechanical resistance and excellent cytocompatibility. In our study, high-strength …

Mucoadhesive chitosan hydrogels as rectal drug delivery vessels to treat ulcerative colitis

J Xu, M Tam, S Samaei, S Lerouge, J Barralet… - Acta biomaterialia, 2017 - Elsevier
Mucoadhesive drug delivery systems stick to mucosal tissues and prolong the local
retention time of drugs. Since the colon is covered by a mucosal layer, mucoadhesive rectal …

Injectable chitosan hydrogels with enhanced mechanical properties for nucleus pulposus regeneration

…, LM Epure, J Antoniou, F Mwale, S Lerouge - … Engineering Part A, 2019 - liebertpub.com
Intervertebral disc (IVD) degeneration has been implicated as a major component of spine
pathology. As the IVD degenerates, the tissue becomes dehydrated, fibrotic, fissured, acellular…

Fabrication and characterisation of amine‐rich organic thin films: Focus on stability

…, C Thérésy, S Lerouge… - Plasma Processes …, 2010 - Wiley Online Library
Thin films, rich in primary amines (CNH 2 ), were deposited from nitrogen (N 2 ) or ammonia
(NH 3 ) and ethylene (C 2 H 4 ) with different gas mixture ratios, R, using three different …

Optimization of injectable thermosensitive scaffolds with enhanced mechanical properties for cell therapy

…, A Adoungotchodo, S Lerouge - Macromolecular …, 2017 - Wiley Online Library
Strong injectable chitosan thermosensitive hydrogels can be created, without chemical
modification, by combining sodium hydrogen carbonate with another weak base, namely, beta‐…

[BOOK][B] Sterilisation of biomaterials and medical devices

S Lerouge, A Simmons - 2012 - books.google.com
The effective sterilisation of any material or device to be implanted in or used in close contact
with the human body is essential for the elimination of harmful agents such as bacteria. …

A rheological approach to assess the printability of thermosensitive chitosan-based biomaterial inks

…, NR Demarquette, S Lerouge - Biomedical …, 2020 - iopscience.iop.org
For extrusion-based bioprinting, the inks must be printable and rapidly present sufficient
mechanical properties to support additional layers and provide a cohesive, manipulable …