The capacity of minocycline to alleviate disease for several neurological disorders in animals
is increasingly being recognised. Indeed, that one drug alone can attenuate the severity of …

Background. Neutralization of central nervous system neurite growth inhibitory factors, for
example, Nogo-A, is a promising approach to improving recovery following spinal cord injury (…

Background Despite the expanding use of machine learning (ML) in fields such as finance
and marketing, its application in the daily practice of clinical medicine is almost non-existent. …

Study Design: Systematic review. Objective: To conduct a systematic review and synthesis of
the literature to assess the comparative effectiveness, safety, and cost-effectiveness of early …

Preclinical studies have attributed neuroprotective properties to the antibiotic minocycline.
Animal studies and early clinical trials support its use in several neurological diseases. In …

Specialized centers of care for spinal cord injury (SCI) were first established in 1944 in
England. The objective of these centers is to improve care and neurological recovery of patients …

OBJECTIVE: The purpose of this study was to compare the clinical efficacy of spinal manipulation
against microdiskectomy in patients with sciatica secondary to lumbar disk herniation (…

Objectives Inadequate postoperative pain control is common and is associated with poor
clinical outcomes. This study aimed to identify preoperative predictors of poor postoperative …

Background Neurofilaments (Nf) are major structural proteins that occur exclusively in neurons.
In spinal cord injury (SCI), the severity of disease is quantified by clinical measures that …

BACKGROUND: Due to uncertain evidence, lumbar fusion for degenerative indications is
associated with the greatest measured practice variation of any surgical procedure. …