Background Contemporary data for causes of vision impairment and blindness form an
important basis of recommendations in public health policies. Refreshment of the Global Vision …

Background Global and regional prevalence estimates for blindness and vision impairment
are important for the development of public health policies. We aimed to provide global …

… tumor-induced T cell apoptosis by downregulating Bax level and augmenting Bcl-2
expression and restore cytokine-dependent Jak-3/Stat-5a signaling pathway in T cells of tumor …

Background Cancer is a major cause of death in children worldwide, and the recorded
incidence tends to increase with time. Internationally comparable data on childhood cancer …

Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one
of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human …

Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly
due to delayed detection. We hypothesized that intercellular communication is critical for …

… constant, σ is ionic conductivity, T is temperature, and E a is the ion-migration activation
energy. We derived E a values from the slope of the ln(σT) versus 1/T of ~0.32 eV for the control …

… Chao, RL Chazdon, RK Colwell & T.-J. Shen, unpublished data); it can be proved for any
abundance models given in Magurran (2004) and Plotkin & Muller-Landau (2002).] …

Background To contribute to the WHO initiative, VISION 2020: The Right to Sight, an
assessment of global vision impairment in 2020 and temporal change is needed. We aimed to …

… We did the pivotal ZUMA-3 trial of KTE-X19 CAR T-cell therapy in the largest population
of adults with relapsed or refractory B-precursor acute lymphoblastic leukaemia to date. KTE-…