Importance Since publication of the report by the Panel on Cost-Effectiveness in Health and
Medicine in 1996, researchers have advanced the methods of cost-effectiveness analysis, …

The rapid growth of human genetics creates countless opportunities for studies of disease
association. Given the number of potentially identifiable genetic markers and the multitude of …

The R environment provides a natural platform for developing new statistical methods due
to the mathematical expressiveness of the language, the large number of existing libraries, …

… with input and critical revisions by Thomas Trikalinos. John Ioannidis evaluated the meta-analyses
published in printed journals; Thomas Trikalinos performed all the statistical analyses…

Objectives: This article summarizes the Agency for Healthcare Research and Quality's
evidence report on the effects of breastfeeding on term infant and maternal health outcomes in …

Background: Studies suggest that vitamin D supplementation may reduce cancer and fracture
risks. Purpose: To examine the benefits and harms of vitamin D with or without calcium …

Background Since the 1997 Dietary Reference Intake (DRI) values for vitamin D and calcium
were established new data have become available on their relationship, both individually …

Background The published clinical research literature may be distorted by the pursuit of
statistically significant results. Purpose We aimed to develop a test to explore biases stemming …

Background Meta-analysis is increasingly used as a key source of evidence synthesis to
inform clinical practice. The theory and statistical foundations of meta-analysis continually …

Background Advances in human genetics could help us to assess prognosis on an individual
basis and to optimise the management of complex diseases. However, different studies on …