In an effort to better understand the phenomenon of lipotoxicity in human β-cells, we evaluated
the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA) (2:1 oleate to …

Background Laparoscopic pancreaticoduodenectomy (LPD) is gaining momentum, but there
is still uncertainty regarding its safety, reproducibility, and oncologic appropriateness. This …

Gene expression analysis may help the management of cancer patients, allowing the
selection of subjects responding to treatment. The aim of this study was the characterization of …

Type 1 diabetes is characterized by T cell-mediated autoimmune destruction of pancreatic β
cells. Several studies have suggested an association between Coxsackie enterovirus …

To shed further light on the primary alterations of insulin secretion in type 2 diabetes and the
possible mechanisms involved, we studied several functional and molecular properties of …

Several properties of pancreatic β-cells in type 2 diabetes (T2D) were studied by using
islets isolated from T2D subjects. Moreover, because metformin has protective effects on …

MicroRNA-21 (miR-21) was reported to be overexpressed and contributes to invasion and
gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC). The aim of this study …

Aims/hypothesis Pancreatic beta cells have highly developed endoplasmic reticulum (ER)
due to their role in insulin secretion. Since ER stress has been associated with beta cell …

Aims/hypothesis Little information is available on the insulin release properties of pancreatic
islets isolated from type 2 diabetic subjects. Since mitochondria represent the site where …

Aims/hypothesis Beta cell loss contributes to type 2 diabetes, with increased apoptosis
representing an underlying mechanism. Autophagy, ie the physiological degradation of damaged …