User profiles for Veena Sangwan

Veena Sangwan

Verified email at mcgill.ca
Cited by 5224

Early steps in cold sensing by plant cells: the role of actin cytoskeleton and membrane fluidity

BL Örvar, V Sangwan, F Omann… - The Plant …, 2000 - Wiley Online Library
Many plants acquire freezing tolerance through cold acclimatization (CA), a prolonged exposure
to low but non‐freezing temperatures at the onset of winter. CA is associated with gene …

Opposite changes in membrane fluidity mimic cold and heat stress activation of distinct plant MAP kinase pathways

V Sangwan, BL Örvar, J Beyerly, H Hirt… - The Plant …, 2002 - Wiley Online Library
Mitogen‐activated protein kinases (MAPKs) appear to be ubiquitously involved in signal
transduction during eukaryotic responses to extracellular stimuli. In plants, no heat shock‐…

Cold‐activation of Brassica napus BN115 promoter is mediated by structural changes in membranes and cytoskeleton, and requires Ca2+ influx

V Sangwan, I Foulds, J Singh, RS Dhindsa - The Plant Journal, 2001 - Wiley Online Library
Previous studies on cold‐triggered events leading to Ca 2+ influx during cold acclimatization
have been conducted on either unicellular cyanobacterium Synechocystis or plant cell …

A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer

R Chugh, V Sangwan, SP Patil, V Dudeja… - Science translational …, 2012 - science.org
Pancreatic cancer is one of the most lethal human malignancies with an all-stage 5-year
survival frequency of <5%, which highlights the urgent need for more effective therapeutic …

The induction of kin genes in cold-acclimating Arabidopsis thaliana. Evidence of a role for calcium

S Tähtiharju, V Sangwan, AF Monroy, RS Dhindsa… - Planta, 1997 - Springer
The involvement of calcium signaling during cold-induction of the kin genes of Arabidopsis
thaliana (L.) Heynh. was examined. Treatments with chemicals which either chelate …

[HTML][HTML] Primary tumors induce neutrophil extracellular traps with targetable metastasis-promoting effects

…, S Rousseau, D Quail, L Walsh, V Sangwan… - JCI insight, 2019 - ncbi.nlm.nih.gov
Targeting the dynamic tumor immune microenvironment (TIME) can provide effective
therapeutic strategies for cancer. Neutrophils are the predominant leukocyte population in mice …

Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways

…, R Chugh, MB Antonoff, D Borja–Cacho, V Sangwan… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Pancreatic adenocarcinoma, among the most lethal human
malignancies, is resistant to current chemotherapies. We previously showed that triptolide inhibits …

Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation

…, N Mujumdar, S Banerjee, V Sangwan… - Molecular cancer …, 2013 - AACR
Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest malignancies, is resistant
to current chemotherapies. We previously showed that triptolide inhibits PDAC cell growth in …

Expression of DRD2 is increased in human pancreatic ductal adenocarcinoma and inhibitors slow tumor growth in mice

…, T Hackert, NA Giese, G Zogopoulos, V Sangwan… - Gastroenterology, 2016 - Elsevier
Background & Aims Incidence of and mortality from pancreatic ductal adenocarcinoma (PDAC),
the most common form of pancreatic cancer, are almost equivalent, so better treatments …

[HTML][HTML] Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase

V Sangwan, GN Paliouras, JV Abella, N Dubé… - Journal of biological …, 2008 - ASBMB
The non-receptor protein-tyrosine phosphatases (PTPs) 1B and T-cell phosphatase (TCPTP)
have been implicated as negative regulators of multiple signaling pathways including …