… Present address: Victoria Baronas is no longer an employee of Hoffmann-La Roche. She
is currently enrolled at the University of British Columbia, Vancouver, BC, Canada. …

Inwardly-rectifying potassium (Kir) channels contribute to maintenance of the resting membrane
potential and regulation of electrical excitation in many cell types. Strongly rectifying Kir …

Kv1.2 is a prominent voltage-gated potassium channel that influences action potential
generation and propagation in the central nervous system. We explored multi-protein complexes …

Therapies with both immunomodulatory and neuroprotective properties are thought to have
the greatest promise in reducing the severity and progression of multiple sclerosis (MS). …

Kv1.2 is a prominent potassium channel subtype in the nervous system and serves as an
important structural template for investigation of ion channel function. However, Kv1.2 voltage-…

Cyclic AMP is thought to facilitate the opening of the HCN2 channel by binding to a C-terminal
domain and promoting or inhibiting interactions between subunits. Here, we correlated …

In excitable cells, ion channel responses to patterned stimuli shape cellular behavior by
regulating the duration, shape, and frequency of action potentials. We have investigated the …

Voltage-gated potassium channels are important regulators of electrical excitation in many
tissues, with Kv1.2 standing out as an essential contributor in the CNS. Genetic deletion of …

Background: The incidence of colorectal cancer (CRC) is decreasing in individuals >50 years
due to organised screening but has increased for younger individuals. We characterized …

Shaker potassium channels have been an essential model for studying inactivation of ion
channels and shaped our earliest understanding of N-type vs. C-type mechanisms. In early …