The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding source
of debate, largely owing to an inability to monitor transient and reversible EMT phenotypes …

Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the
major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, …

Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led to …

Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links between …

Heterochromatin has been defined as deeply staining chromosomal material that remains
condensed in interphase, whereas euchromatin undergoes de-condensation 1 . …

Metastasis is the major cause of cancer-related deaths; therefore, the prevention and treatment
of metastasis are fundamental to improving clinical outcomes. Epithelial mesenchymal …

During embryogenesis, endothelial cells induce organogenesis before the development of
circulation 1 , 2 , 3 , 4 . These findings suggest that endothelial cells not only form passive …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they act …

Myelosuppression damages the bone marrow (BM) vascular niche, but it is unclear how
regeneration of bone marrow vessels contributes to engraftment of transplanted hematopoietic …

Advanced human cancers are invariably aneuploid, in that they harbour cells with abnormal
chromosome numbers 1 , 2 . However, the molecular defects underlying this trait, and …