The systematic translation of cancer genomic data into knowledge of tumour biology and
therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust …

Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves
response of mammary carcinomas to chemotherapy. Herein we identify interleukin (IL)-10 …

Lyn-deficient mice were generated to analyze the role of Lyn in B cell antigen receptor (BCR)
signaling. These mice had a reduced number of peripheral B cells with a greater …

Genetic studies have identified mutations in key regulators of the Wnt/β-catenin pathway in
a variety of cancers, most frequently in colon cancers. However, whether the pathway is …

To evaluate whether β-catenin signaling has a role in the regulation of angiogenesis in
colon cancer, a series of angiogenesis-related gene promoters was analyzed for β-catenin/TCF …

Increased airway smooth muscle (ASM) mass is perhaps the most important component of
the airway wall remodeling process in asthma. Known mediators of ASM proliferation in cell …

Purpose: The majority of tumor-specific antigens are intracellular and/or secreted and therefore
inaccessible by conventional chimeric antigen receptor (CAR) T-cell therapy. Given that …

Background: To elucidate the role of the Src family kinase Lyn in B cell receptor (BCR)
signaling, we and others previously generated lyn −/− mice and analyzed their B cell responses. …

The hemoglobin molecule is a tetramer consisting of 2 pairs of globin chains, each of which
contains a heme group. During fetal development, the major hemoglobin is Hb F (2 2). In a …

Rationale: Altered airway smooth muscle (ASM) function and enrichment of the extracellular
matrix (ECM) with fibronectin and collagen are key features of asthma. Previously, we have …