Regulation of the effects of TGF-β1 by activation of latent TGF-β1 and differential expression of TGF-β receptors (TβR-I and TβR-II) in idiopathic pulmonary fibrosis

N Khalil, TV Parekh, R O'connor, N Antman, W Kepron… - Thorax, 2001 - thorax.bmj.com
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is characterised by subpleural fibrosis
that progresses to involve all areas of the lung. The expression of transforming growth factor-…

Epinephrine fails to hasten hemodynamic recovery in fully developed canine anaphylactic shock

…, AB Becker, K Duke, M Tillett, W Kepron… - International archives of …, 2002 - karger.com
Background: Epinephrine (Epi) is the treatment of choice for reversing cardiovascular
collapse in anaphylactic shock (AS). However, there are few data supporting its use in this …

Mechanical alterations of airway smooth muscle in a canine asthmatic model

…, RW Mitchell, EA Kroeger, W Kepron… - Journal of Applied …, 1979 - journals.physiology.org
METHODS IgE antibody production was induced by immunizing newborn mongrel dogs
with 10 pg of a conjugate of dinitrophenol and ovalbumin (DNPZ-OA) mixed in 30 mg of …

Risk factors for death from asthma

…, S Tough, FHY Green, D Cockcroft, W Kepron… - Annals of Allergy …, 1999 - Elsevier
BACKGROUND: Asthma mortality rates have increased in Canada and worldwide. Within
Canada, the highest rates were seen in the prairie provinces. OBJECTIVE: The objective was …

Bronchial smooth muscle mechanics of a canine model of allergic airway hyperresponsiveness

…, K Rao, AJ Halayko, W Kepron… - Journal of applied …, 1992 - journals.physiology.org
Although we have reported that tracheal smooth muscle from sensitized dogs shows altered
mechanical properties, we did not know, because of technical difficulties with the preparation…

Histamine H3 receptor blockade improves cardiac function in canine anaphylaxis

…, E Bautista, K Duke, A Becker, W Kepron… - American journal of …, 1999 - atsjournals.org
In anaphylactic shock (AS), the relative effects of the autacoids including histamine,
prostaglandins, and leukotrienes on causing cardiovascular collapse and the extent to which …

Effect of maintenance azithromycin on established bronchiolitis obliterans syndrome in lung transplant patients

NR Porhownik, W Batobara, W Kepron… - Canadian respiratory …, 2008 - hindawi.com
BACKGROUND: Bronchiolitis obliterans syndrome (BOS), the main cause of late mortality
following lung transplantation, is defined as an irreversible decline in forced expiratory volume …

The ventilatory response to hypercapnia and to hypoxemia in chronic obstructive lung disease

W Kepron, RM Cherniack - American Review of Respiratory …, 1973 - atsjournals.org
W.: Respiratory sensitivity to acute hypoxia in man born at sea level living at high altitude, J.
W.: Irreversible respiratory insensitivity to acute hypoxia in man born at high altitude, J. Appl. …

Effect of bolus epinephrine on systemic hemodynamics in canine anaphylactic shock

…, J Elkin, S Sharma, H Unruh, W Kepron - Cardiovascular …, 1998 - academic.oup.com
Objective: Epinephrine (Epi) is considered to be the drug of choice for anaphylactic shock (AS).
However, the benefit of this drug on improving systemic hemodynamics in AS has never …

North American blastomycosis in Central Canada: a review of 36 cases

MW Kepron, CB Schoemperlen… - Canadian Medical …, 1972 - ncbi.nlm.nih.gov
Experience with 36 cases of North American blastomycosis in Central Canada is reported.
Symptoms referable to the respiratory tract predominated, but no uniform clinical pattern for …