Breast cancer progression involves multiple genetic events, which can activate dominant-acting
oncogenes and disrupt the function of specific tumor suppressor genes. This article …

The phosphatidyl inositol 3-kinase (PI3K)/Akt pathway is activated downstream of a variety
of extracellular signals and activation of this signaling pathway impacts a number of cellular …

One-third of patients with breast cancer overexpress the ERBB2 receptor tyrosine kinase,
which is associated not only with a more aggressive phenotype but also reduced …

Background There are many pharmacologic therapies that are being used or considered for
treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated …

Background Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract
infection and hospitalization in infants. Nirsevimab is a monoclonal antibody to the RSV fusion …

The effect of mammary gland-specific expression of the polyomavirus middle T antigen was
examined by establishing lines of transgenic mice that carry the middle T oncogene under …

Overexpression and amplification of the neu (c-erbB2, ERBB2) protooncogene have been
implicated in the development of aggressive human breast cancer. To directly assess the …

We have used transgenic mice that carry an activated c-neu oncogene driven by a mouse
mammary tumor virus (MMTV) promoter to assess the stepwise progression of carcinogenesis …

Animal models are powerful tools to analyze the mechanism of the induction of human breast
cancer. Here we report a detailed analysis of mammary tumor progression in one mouse …

Nirsevimab to Prevent RSV Illness in Infants Nirsevimab, a monoclonal antibody targeting
respiratory syncytial virus, protected against RSV-associated hospitalization and severe …