Camptothecin, a cytotoxic drug, is a strong inhibitor of nucleic acid synthesis in mammalian
cells and a potent inducer of strand breaks in chromosomal DNA. Neither the equilibrium …

Publisher Summary This chapter discusses the DNA topoisomerases as anticancer drug
targets. Much progress has been made in recent years in understanding the mechanism of …

Camptothecin, a plant alkaloid with antitumor activity, has been shown to be a potent inhibitor
of nucleic acid synthesis and a strong inducer of DNA strand breaks in mammalian cells. …

Camptothecin, which induces an unusual type of DNA damage by trapping cellular
topoisomerase I on chromosomal DNA in the form of drug-enzyme-DNA cleavable complexes, …

Cordyceps militaris (C. militaris) is a fungus with a long history of widespread use in folk
medicine, and its biological and medicinal functions are well studied. A crucial pharmacological …

20(S)-Camptothecin, the 20(S)-camptothecin sodium salt, and 12 analogues with
substituents on the A ring differ widely in their effectiveness in the treatment of murine L1210 …

OBJECTIVE. Our objective was to determine whether multidetector CT (MDCT) angiography
is an accurate and reliable method of revealing atheroocclusive disease of the aortoiliac …

The intracellular level of DNA topoisomerase II appears to be reversibly regulated by serum
concentration in cultured primary human skin fibroblasts (HSF). Upon serum starvation, the …

Purpose: This study evaluated perioperative variables to predict death in nonruptured and
ruptured abdominal aortic aneurysm (AAA) surgery. Methods: A consecutive review of all …

Impaired angiogenesis could contribute to the increased incidence of coronary and peripheral
artery disease in diabetic patients. Angiogenesis is initiated by vascular endothelial …