Background and aims Acute appendicitis (AA) is among the most common causes of acute
abdominal pain. Diagnosis of AA is still challenging and some controversies on its …

Background: Bleeding is the most frequent cause of preventable death after severe injury.
Coagulopathy associated with severe injury complicates the control of bleeding and is …

Although most patients with acute pancreatitis have the mild form of the disease, about 20–30%
develops a severe form, often associated with single or multiple organ dysfunction …

Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine
production, viral RNA and a sustained interferon (IFN) response, all of which are recapitulated …

We have developed an approach using Bayesian networks to predict protein-protein
interactions genome-wide in yeast. Our method naturally weights and combines into reliable …

… Therefore, our data strongly suggest that binding of NF-Y and XBP1 to the ERSE is spatially
constrained in a single orientation that promotes the formation of an NF-Y/XBP1 dimer. Lastly…

Background Medical practitioners use survival models to explore and understand the
relationships between patients’ covariates (eg clinical and genetic features) and the effectiveness …

N 6 -methyladenosine (m 6 A) is the most common and abundant messenger RNA
modification, modulated by ‘writers’, ‘erasers’ and ‘readers’ of this mark 1 , 2 . In vitro data have …

… in a step-like classification vector on conditions (y). Reapplying the transpose of the matrix A
… x and y that solve the coupled eigenvalue problems A T Ax = λ 2 x and AA T y = λ 2 y (where …

The heterogeneous nature of mammalian PRC1 complexes has hindered our understanding
of their biological functions. Here, we present a comprehensive proteomic and genomic …