User profiles for Yannick Le Manach
Yannick LE MANACHMcMaster University, PHRI Verified email at phri.ca Cited by 13732 |
Statistical evaluation of a biomarker
A biomarker may provide a diagnosis, assess disease severity or risk, or guide other clinical
interventions such as the use of drugs. Although considerable progress has been made in …
interventions such as the use of drugs. Although considerable progress has been made in …
The prognostic value of pre-operative and post-operative B-type natriuretic peptides in patients undergoing noncardiac surgery: B-type natriuretic peptide and N …
Objectives : The objective of this study was to determine whether measuring post-operative
B-type natriuretic peptides (NPs) (ie, B-type natriuretic peptide [BNP] and N-terminal …
B-type natriuretic peptides (NPs) (ie, B-type natriuretic peptide [BNP] and N-terminal …
Randomized evidence for reduction of perioperative mortality
…, A Corcione, A Slullitel, L Cabrini, Y Le Manach… - Journal of cardiothoracic …, 2012 - Elsevier
OBJECTIVE: With more than 220 million major surgical procedures performed annually,
perioperative interventions leading to even minor mortality reductions would save thousands of …
perioperative interventions leading to even minor mortality reductions would save thousands of …
Quantifying the impact of different approaches for handling continuous predictors on the performance of a prognostic model
Continuous predictors are routinely encountered when developing a prognostic model.
Investigators, who are often non‐statisticians, must decide how to handle continuous predictors …
Investigators, who are often non‐statisticians, must decide how to handle continuous predictors …
[HTML][HTML] Evaluation of a novel closed-loop fluid-administration system based on dynamic predictors of fluid responsiveness: an in silico simulation study
Introduction Dynamic predictors of fluid responsiveness have made automated management
of fluid resuscitation more practical. We present initial simulation data for a novel closed-…
of fluid resuscitation more practical. We present initial simulation data for a novel closed-…
Poor intraoperative blood glucose control is associated with a worsened hospital outcome after cardiac surgery in diabetic patients
A Ouattara, P Lecomte, Y Le Manach… - The Journal of the …, 2005 - pubs.asahq.org
Background Tight perioperative control of blood glucose improves the outcome of diabetic
patients undergoing cardiac surgery. Because stress response and cardiopulmonary bypass …
patients undergoing cardiac surgery. Because stress response and cardiopulmonary bypass …
[HTML][HTML] Aspirin in patients undergoing noncardiac surgery
…, M Graham, L Pasin, Y Le Manach… - … England Journal of …, 2014 - Mass Medical Soc
Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …
Assessing the diagnostic accuracy of pulse pressure variations for the prediction of fluid responsiveness: a “gray zone” approach
M Cannesson, Y Le Manach, CK Hofer… - The Journal of the …, 2011 - pubs.asahq.org
Background Respiratory arterial pulse pressure variations (PPV) are the best predictors of
fluid responsiveness in mechanically ventilated patients during general anesthesia. However, …
fluid responsiveness in mechanically ventilated patients during general anesthesia. However, …
Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study
…, JT Tumukunde, TM Esterhuizen, Y Le Manach… - The Lancet, 2018 - thelancet.com
Background There is a need to increase access to surgical treatments in African countries,
but perioperative complications represent a major global health-care burden. There are few …
but perioperative complications represent a major global health-care burden. There are few …
[HTML][HTML] Clonidine in patients undergoing noncardiac surgery
…, M Graham, L Pasin, Y Le Manach… - … England Journal of …, 2014 - Mass Medical Soc
Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …