A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling
is essential for chronic pain hypersensitivity. Using multiple approaches, we found that …

Microglia–neuron signalling in the spinal cord is a key mediator of mechanical allodynia
caused by peripheral nerve injury. We recently reported sex differences in microglia in pain …

Insulin resistance is a chronic inflammatory condition accompanying obesity or high fat diets
that leads to type 2 diabetes. It is hypothesized that lipids and gut bacterial compounds in …

Neonatal hindpaw incision primes developing spinal nociceptive circuitry, resulting in
enhanced hyperalgesia following reinjury in adulthood. Spinal microglia contribute to this …

The dominant view in the field of pain is that peripheral neuropathic pain is driven by microglia
in the somatosensory processing region of the spinal dorsal horn. Here, to the contrary, …

NMDA receptors (NMDARs) are critical for physiological synaptic plasticity, learning, and
memory and for pathological plasticity and neuronal death. The GluN1 subunit is encoded by a …

Background and Purpose Chronic pain is a devastating problem affecting one in five individuals
around the globe, with neuropathic pain the most debilitating and poorly treated type of …

NMDA receptor (NMDAR)-mediated fast excitatory neurotransmission is implicated in a
broad range of physiological and pathological processes in the mammalian central nervous …

Stroke in the neonatal brain frequently results in neurologic impairments including cognitive
disability. We investigated the effect of long-term sodium valproate (valproate) and …

The electrocatalytic reduction of SO 2 to produce H 2 S is a critical approach for achieving
the efficient utilization of sulfur resources. At the core of this approach for commercial …