Background Macitentan is beneficial for long-term treatment of pulmonary arterial
hypertension. The microvasculopathy of chronic thromboembolic pulmonary hypertension (CTEPH) …

Introduction: We set out to determine the frequency of respiratory symptoms, abnormal lung
function, and shrinking lung syndrome (SLS) among patients with systemic lupus …

Dog left upper lobes (LUL) were perfused in situ via the left lower lobe artery. Lobe weight
was continuously monitored. Increasing lobar flow from normal to 10 times normal had little …

Inspiratory muscle output is downregulated when the mechanical load is reduced in awake
humans. It is not known whether this is related to reduction in PCO2 or to removal of load-…

Eight patients with crush syndrome were treated in our department during the Lebanon War,
1982. They arrived after having been trapped under fallen masonry for 4 to 28 h. They all …

Objectives Lung cancer is one of the most lethal cancers. Currently, there are no biomarkers
for early detection, monitoring treatment response, and detecting recurrent lung cancer. We …

After voluntary hyperventilation, normal humans do not develop a significant ventilatory
depression despite low arterial CO2 tension, a phenomenon attributed to activation of a brain …

The respiratory response to CO 2 during pressure-support ventilation (PSV) was studied in
16 conscious normal humans. The subjects breathed through a mouthpiece connected to a …

BACKGROUND: Bronchiolitis obliterans syndrome (BOS), the main cause of late mortality
following lung transplantation, is defined as an irreversible decline in forced expiratory volume …

The metabolic demands of the body, including consumption of oxygen and removal of carbon
dioxide, vary widely in health and disease. Ventilation must adjust to meet these demands …