Germline BRCA Mutations in a Large Clinic-Based Cohort of Patients With Pancreatic Adenocarcinoma
Purpose The main purpose of this study was to determine the prevalence of pathogenic
BRCA1 and BRCA2 mutations in a consecutively ascertained clinic-based cohort of patients …
BRCA1 and BRCA2 mutations in a consecutively ascertained clinic-based cohort of patients …
Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer
Background & Aims We investigated the prevalence of germline mutations in APC, ATM,
BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 …
BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 …
Clinical and genomic characterisation of mismatch repair deficient pancreatic adenocarcinoma
RC Grant, R Denroche, GH Jang, KM Nowak, A Zhang… - Gut, 2021 - gut.bmj.com
Objective To describe the clinical, pathological and genomic characteristics of pancreatic
cancer with DNA mismatch repair deficiency (MMRD) and proficiency (MMRP). Design We …
cancer with DNA mismatch repair deficiency (MMRD) and proficiency (MMRP). Design We …
Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome
Introduction Transcriptional analyses have identified several distinct molecular subtypes in
pancreatic ductal adenocarcinoma (PDAC) that have prognostic and potential therapeutic …
pancreatic ductal adenocarcinoma (PDAC) that have prognostic and potential therapeutic …
Candidate DNA repair susceptibility genes identified by exome sequencing in high-risk pancreatic cancer
AL Smith, N Alirezaie, A Connor, M Chan-Seng-Yue… - Cancer letters, 2016 - Elsevier
The genetic basis underlying the majority of hereditary pancreatic adenocarcinoma (PC) is
unknown. Since DNA repair genes are widely implicated in gastrointestinal malignancies …
unknown. Since DNA repair genes are widely implicated in gastrointestinal malignancies …
Exome-wide association study of pancreatic cancer risk
We conducted a case-control exome-wide association study to discover germline variants in
coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We …
coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We …
Pancreatic cancer
RS Mateos, KC Conlon - Surgery (Oxford), 2016 - Elsevier
It is anticipated that by 2030 pancreatic cancer will be the second leading cause of death
from cancer. Surgery remains the only potentially curative therapy. However, less than a …
from cancer. Surgery remains the only potentially curative therapy. However, less than a …
Reflex Testing for Germline BRCA1, BRCA2, PALB2, and ATM Mutations in Pancreatic Cancer: Mutation Prevalence and Clinical Outcomes From Two Canadian …
AL Smith, C Wong, A Cuggia, A Borgida… - JCO precision …, 2018 - ascopubs.org
Purpose We investigated the translational value of reflex testing for germline mutations in
four homology-directed DNA repair predisposition genes (BRCA1, BRCA2, PALB2, and …
four homology-directed DNA repair predisposition genes (BRCA1, BRCA2, PALB2, and …
Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer
Y Feng, H Liu, B Duan, Z Liu, J Abbruzzese… - …, 2019 - academic.oup.com
The AURORA pathway participates in mitosis and cell division, and alterations in mitosis
and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA …
and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA …
Is Biannual Surveillance for Pancreatic Cancer Sufficient in Individuals With Genetic Syndromes or Familial Pancreatic Cancer?
Background: Individuals with a family history of pancreatic adenocarcinoma (PC) or with a
germline mutation in a PC susceptibility gene are at increased risk of developing PC. These …
germline mutation in a PC susceptibility gene are at increased risk of developing PC. These …