One of the most common challenges of randomized controlled trials (RCTs), both published
and unpublished, is related to problems with recruitment. Investigators' enthusiasm for …

BACKGROUND: The low recruitment rates into surgical randomized controlled trials (RCTs)
threaten the validity of their findings. We reviewed the reasons for nonentry of eligible …

Randomized controlled trials in surgery are notoriously difficult to design and conduct due to
numerous methodological and cultural challenges. Over the last 5 years, several UK-based …

A randomised controlled trial (RCT) is considered the hierarchical peak of evidence-based
medicine and a general demand for any result to be evaluated by RCTs has evolved. Yet …

reported data derived from a randomized trial, whereas 46% were based on case series. A
decade later (2006), we conducted a similar survey and found that the relative percentage of …

Abstract Background Randomised controlled trials (RCTs) in surgery are complex to design
and conduct and face unique challenges compared to trials in other specialties. The …

The application of evidence-based care in the practice of surgery has improved in the past
decade (ie, colorectal surgery, arthroplasty surgery), 1, 2 but surgical treatments are still less …

Abstract Rationale Randomised controlled trials (RCTs) of surgical interventions are
increasing. Such trials encounter challenges that are not present in RCTs of non-surgical …

Background Well-designed randomised clinical trials (RCTs) provide the best evidence to
inform decision-making and should be the default option for evaluating surgical procedures …

Objective The aim of the study was to investigate how doctors considered and experienced
the concept of equipoise while recruiting patients to randomized controlled trials (RCTs) …