The modern management of rectal cancers continues to evolve. With the release of data
from new landmark randomized controlled trials (RAPIDO, PRODIGE-23), total neoadjuvant …

Total neoadjuvant therapy (TNT) for rectal cancer is the preoperative delivery of radiation or
chemoradiotherapy as well as systemic chemotherapy for the purpose of improving …

Despite preoperative chemoradiotherapy (CRT) and total mesorectal excision improving the
local control for locally advanced rectal cancer (LARC), oncologic outcomes and survival …

A few months ago, results from two randomised phase III trials of total neoadjuvant therapy
(TNT) in locally advanced rectal cancer were presented (RAPIDO and PRODIGE 23) …

The standard treatments for locally advanced rectal cancer typically involved neoadjuvant
therapy with either short-course radiation or long-course chemoradiation, followed by radical …

Objective: To evaluate the impact of neoadjuvant multi-agent systemic chemotherapy and
radiation (TNT) vs neoadjuvant single-agent chemoradiation (nCRT) and multi-agent …

The treatment of locally advanced rectal cancer (LARC) has benefited from improved
surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT) …

Purpose To assess the efficacy of total neoadjuvant therapy (TNT) for rectal carcinoma in
comparison with conventional chemoradiotherapy (CRT). Methods A systematic review was …

Background: The addition of induction chemotherapy to concomitant neoadjuvant
chemoradiation in locally advanced rectal cancer could increase pathological downstaging …

Abstract Treatment modalities in rectal cancer have undergone a slow, evolutionary
transition over the past 30 years. More recently, contemporary descriptions of advanced …