1). 5, 10 At revision surgery, the periprosthetic bone loss observed radiographically contains
an inflammatory membrane. Histologic analysis of the inflammatory membrane obtained at …

Periprosthetic bone loss is an important contributory factor for aseptic loosening of total joint
replacements. It has recently been shown that osteoclast precursor cells are present in the …

Macrophage phagocytosis of cement particles with production of inflammatory mediators is a
component of the underlying mechanism of aseptic loosening of joint prostheses …

Monocytes or macrophages form important accessory cells in the regulation of bone
metabolism and destruction. Cells of the mononuclear phagocyte lineage form the precursor …

Macrophages, activated by particulate wear debris, are important in the process of
osteolysis, which occurs during joint implant loosening. We previously found increased …

OBJECTIVE In aseptic loosening, a heavy macrophage response to biomaterial wear
particles is commonly found in arthroplasty tissues. The aim of this study was to discover if …

Since the recognition of aseptic loosening by Charnley in the early 1960s, much information
has been gained on the basic science of periprosthetic bone loss. Initially termed cement …

An important cause of prosthetic loosening is bone resorption that results from the
interaction of macrophages with implant surfaces and particulate debris. The mediators …

Total hip arthroplasty (THA) has provided dramatic pain relief and improvement in function
for millions of patients with end-stage arthritis; however, periprosthetic osteolysis following …

Particulate wear debris from bone cement or prosthetic components can stimulate
macrophages to cause bone resorption. We compared the effect of particle composition …