Background Randomized controlled trials (RCTs) are thought to provide the most accurate
estimation of “true” treatment effect. The relative quality of effect estimates derived from …

Breast cancer is the most commonly diagnosed cancer among women. To date, the use of
efficacy randomized controlled trials (RCTs) in breast cancer have resulted in dramatic …

Breast cancer remains the most common cancer diagnosed in women and the second
leading cause of cancer-related deaths in this group. Significant advances in the treatment …

THE INSTITUTE OF MEDICINE DEFINES THE QUALITY OF health care as the “degree to
which health services for individuals and populations increase the likelihood of desired …

Background Interpretation of randomized controlled trials (RCTs) without a significant
difference regarding the primary outcome (negative RCTs) is frequently challenging, due to …

Importance Randomized clinical trials (RCTs) provide the highest level of evidence to
evaluate 2 or more surgical interventions. Surgical RCTs, however, face unique challenges …

Background Meta-analysis of randomized clinical trials (RCTs) with low risk of bias is
considered the highest level of evidence available for evaluating an intervention. Bias in …

Objective: We aimed to compare treatment effect estimates from NRSs with PS analysis and
RCTs of surgery. Background: Evaluating a surgical procedure in randomized controlled …

OBJECTIVE: To compare the results of meta-analysis of nonrandomized comparative
studies (NRCSs) of a surgical procedure with that of randomized controlled trials (RCTs) …

Objective: This study aimed to assess the reported quality of trials in operative surgery.
Summary Background Data: Randomized controlled trials (RCTs) in operative surgery have …