Background Fibrin sealants are used increasingly in surgery to reduce bleeding and
improve wound healing. They have great potential as biocompatible, biodegradable drug …

This chapter summarizes the research experience using a commercial pooled fibrin sealant
(FS) as the delivery vehicle, both in vitro and in vivo, for several drugs and biologies. The …

Background: Animal studies have shown that continuous infusion of beta-lactam antibiotics
is more effective than intermittent dosing. We studied several dosing regimens of cefazolin in …

Commercially prepared fibrin sealants have been available in Europe and Japan for many
years. However, current formulations are exclusively two-component, liquid fibrin sealants …

Introduction: Fibrin sealants (FS) have been used for many years to facilitate hemostasis and
to provide suture support and sealing/adhesion of tissues after surgery. While their …

Background Fibrin sealant is a two-component topical hemostat, sealant, and tissue
adhesive consisting of fibrinogen and thrombin that has been used in the United States as a …

Fibrin sealants can be a valuable adjunct to surgical procedures. A variety of commercial
products have been developed. Specific uses include hemostasis, tissue sealing, and even …

• Topical application of antibiotics is used in the prophylaxis of postoperative surgical
infections. However, whether topically applied antibiotics remain primarily in the surgical …

Background. Fibrin sealant became the first modern era material approved as a hemostat in
the United States in 1998. It is the only agent presently approved as a hemostat, sealant …

Background. Perioperative administration of cefazolin reduces the incidence of
perioperative infections. Intraoperative re-dosing of cefazolin is commonly given between 2 …