BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway

…, R Hagelaar, BMT Vervoort, TM Tee… - Blood, The Journal …, 2021 - ashpublications.org
Asparaginase (ASNase) therapy has been a mainstay of acute lymphoblastic leukemia (ALL)
protocols for decades and shows promise in the treatment of a variety of other cancers. To …

Probenecid as a noninjurious positive inotrope in an ischemic heart disease murine model

…, U Singh, M Jiang, X Ren, T Tee… - Journal of …, 2013 - journals.sagepub.com
The current therapeutic options for acute decompensated heart failure are limited to afterload
reducers and positive inotropes. The latter increases myocardial contractility through …

Continuous Instrument Tracking in a Cerebral Corticectomy Ex Vivo Calf Brain Simulation Model: Face and Content Validation

…, N Abou Hamdan, R Yilmaz, T Tee… - Operative …, 2022 - journals.lww.com
METHODS: An ex vivo calf brain simulation model was developed in which trainees performed
a subpial corticectomy of three defined areas. A case series study assessed face and …

MLL (KMT2A)-rearranged Acute Lymphoblastic Leukemias Are Addicted to S-Adenosyl Methionine (SAM): Implications for Therapy

T Tee, T Ruiter, D Wajon, S Wu, A Dahaoui… - Blood, 2022 - ashpublications.org
MLL (KMT2A)-rearranged acute lymphoblastic leukemia (MLLr ALL) is an aggressive subset
associated with poor survival and relapse representing 5% of childhood ALL cases and 75…

C-CASE 2023: Promoting Excellence in Surgical Education01. Near-peer tutoring: an effective adjunct for virtual anatomy learning02. Surgical Exploration and …

…, A Ghasroddashti, ED Patterson, M Bondok, T Tee… - 2023 - canjsurg.ca
Background: The start of the COVID-19 pandemic caused a shift in medical education from
the classroom to the virtual setting. This abrupt change led to an increase in stress among …

SP11. 14 Evaluating the Efficacy and Cognitive Load of a Real-Time Intelligent Coaching System versus Human Expert Instruction in Surgical Technical Skills Training …

T Tee, R Yilmaz, A Fazlollahi, M Bakhdair… - British Journal of …, 2023 - academic.oup.com
Aims An artificial intelligence-driven tutoring system provides risk-free training on realistic
simulated procedures and objective assessment to improve surgical technical skills. This study …

[HTML][HTML] Methionine Restriction As a Novel Therapeutic Strategy for MLL (KMT2A)-Rearranged Acute Lymphoblastic Leukemia

T Tee, T Ruiter, A Dahaoui, D van Ingen Schenau… - Blood, 2021 - Elsevier
Background: MLL (KMT2A)-rearranged acute lymphoblastic leukemia (MLLr ALL) is a rare
but aggressive subset that represents 5% of childhood ALL cases, and accounts for about 70…

C-CASE 2022: Competence to Excellence01. The Queen Bee phenomenon in Canadian surgical subspecialties: an evaluation of gender biases in the resident …

…, N Stachura, K Grewal, R Yilmaz, S Mahmood, T Tee… - 2022 - canjsurg.ca
Background The Queen Bee phenomenon describes the behavioural response that occurs
when women achieve success in a male-dominated environment, and in this position of …

Subpial resection in a novel ex vivo calf brain epilepsy simulation model

…, R Yilmaz, M Eskandari, T Tee… - … Journal of Surgery, 2022 - search.proquest.com
Background: Epilepsy surgery or subpial resection involves surgical removal of cortical
tissue lesions. This resection technique is a critical bimanual task that is often mastered by …

C-CASE 2022: Competence to Excellence: Canadian Conference for the Advancement of Surgical Education, Oct. 13–14, 2022.

L Goff, H Greene, A Munn, A Furey… - … Journal of Surgery, 2022 - search.ebscohost.com
… This will evaluate the program from both mentor and mentee perspectives with a unique
lens … Trisha Tee, Puja Pachchigar, Bilal Tarabay, Recai Yilmaz, Rolando Del Maestro. From …