Absolute |
Active internal bleeding |
|
History of stroke within 2 mo |
|
Bleeding diathesis |
|
Surgical procedure within 10 d |
|
Intracranial neoplasm, arteriovenous malformation or aneurysm |
|
Severe uncontrolled hypertension (> 200 mm Hg systolic or > 110 mm Hg diastolic) |
|
Recent traumatic cardiopulmonary resuscitation |
|
Relative |
Significant gastrointestinal bleeding or active peptic ulcer within 10 d |
|
Evidence of transient ischemic attacks |
|
High likelihood of left heart thrombus |
|
Genitourinary bleeding within 10 d |
|
Acute pericarditis |
|
Subacute bacterial endocarditis |
|
Hemostatic defects including those secondary to severe hepatic or renal disease |
|
Significant liver dysfunction |
|
Pregnancy or less than 28 days post-partum |
|
Diabetic hemorrhagic retinopathy or other hemorrhagic ophthalmic conditions |
|
Septic thrombophlebitis or occluded arteriovenous cannula at seriously infected site |
|
Streptokinase therapy in the previous 6 mo |
|
Confirmed streptococcal infection |